ANGIOSUPPRESSIVE PROPERTY OF SULFATED POLYSACCHARIDES GEL DISC FROM SARGASSUM OLIGOCYSTUM MONTAGNE

RICHIE G. BAYURAN

Abstract

Algae are the group of marine photosynthetic microorganisms with diverse biological and pharmacological activities. Angiogenesis plays a vital role in sustaining a growing body but over activity of this mechanism can lead to tumor formation. This study was conducted to determine the angiosuppressive property of sulfated polysaccharides (SPs) from Sargassum oligocystum using chorioallantoic membrane (CAM) assay. Hot water extraction and lyophilization were used to extract SPs with a yield of 8.56%. FTIR characterization of SPs showed identical spectra with the reference standard under 650 to 4000cm-1. CAM model was used to assess the effect of SPs on angiogenesis. One-way ANOVA and DMRT revealed that 100mg of SPs disc did not differ significantly when compared to retinoic acid at p<0.01. The result suggested that the SPs from S. oligocystum is a promising alternative for inhibition of angiogenesis. Thus, the use of specific cancer cell line is recommended.